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Bristol-Myers Squibb and Pfizer Provide Revise on Apixaban Clinical Advancement Program Bristol-Myers Squibb Firm and Pfizer Inc provided an update on the apixaban clinical development program. The companies announced that new Stage II data in acute coronary syndrome patients will be provided at the upcoming getting together with of the European Culture of Cardiology . In addition, Bristol-Myers Squibb and Pfizer reported that an early evaluation of results from a Stage III research of apixaban for the prevention of venous thromboembolism in individuals undergoing total knee substitute indicates that the principal endpoint of the study had not been met. The Phase III VTE prevention study known as ADVANCE-1 compared apixaban, a novel, oral Aspect Xa inhibitor given at a dosage of 2.5 mg, daily twice, to the FDA-approved dosage of enoxaparin, 30 mg daily given twice.