She examined the genes in the mind areas – – the hippocampus and amygdala – – commonly associated with major depression in rats and humans. Then she required four genetically different strains of rats and exposed them to chronic tension for two weeks. Later on, she recognized the genes that experienced consistently increased or reduced in response to the stress in every four strains in the same human brain regions. Redei right now had one group of depression-related genes that came out of an animal style of depression and one group of stress-related genes that came our of her chronic tension study. Next she compared the two sets of genes to discover if there have been any similarities. ‘If the ‘stress causes depression theory’ was correct, there should have been a significant overlap between these two pieces of genes,’ she said.They have found that by doing this the immune system now recognizes regions of the HER-2/neu molecule that are not immunogenic when offered by additional vaccine approaches. Paterson 1st hit on the idea of using Listeria as a cancer vaccine vector over ten years ago. ‘It took a while to dissect what components of an immune response had been best able to cause the rejection of set up tumors,’ she says. ‘But in the last couple of years it has paid and we are very excited to see the technology finally being examined in tumor patients. The imagine the cancers immunotherapist is to provide an alternative and more humane method of controlling metastatic disease than current chemotherapies.’ The Listeria vector happens to be being ready for a scientific trial targeting a tumor antigen connected with cervical cancers by Advaxis Inc., a cancer vaccine biotech company that has certified Penn patents on the use of Listeria monocytogenes as a vaccine vector.