Arginase-2 enzyme plays a significant role in diabetic nephropathy The enzyme arginase-2 plays a major role in kidney failure, and blocking the action of this enzyme can lead to protection against renal disease in diabetes, according to researchers. We believe these arginase inhibitors may be among the new targets that can decelerate the progression of, or avoid the development of even, end-stage renal disease, said Alaa S. Awad, associate professor of nephrology, Penn Condition College of Medicine himcolin us . In the United States diabetes may be the leading reason behind end-stage renal disease – – kidney failure – – causing almost 45 % of most cases.
Texas, in the meantime, reached a $158 million settlement with Janssen in January in which the company did not admit fault. Jurors in Arkansas weren’t told about the monetary stakes during 10 days of testimony, beyond that Janssen could have observed a $200 million swing in its revenues if it issued alarming warnings that the medication could cause excess weight gain, diabetes and other health results. The award that Fox will decide would move toward the state’s Medicaid fund, which is definitely facing a projected $400 million deficit next year. Jurors had a set of 10 questions to decide – five concerning Janssen and five for its Johnson & Johnson parent company. The jury ruled in favor of the state on all 10 questions.