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Their follow-up studies with NASA collaborators showed altered disease-related responses for Pseudomonas aeruginosa and a methicillin resistant Staphylococcus aureus strain when subjected to either spaceflight or spaceflight-analogue circumstances produced on the planet. To simulate microgravity on earth, an apparatus known as a rotating wall structure vessel bioreactor is used. This cylindrical device rotates cells, keeping them in suspension in low fluidic conditions relevant to those they encounter in spaceflight and in our body during infection. Nickerson and her co-workers demonstrated that a conserved protein referred to as Hfq serves as a master regulator that controls Salmonella and additional bacterial pathogen responses to spaceflight and spaceflight analogue conditions.