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Dysregulated Wnt signaling is definitely associated with many cancers.

Further, David colleagues and Thomas, at Peter MacCallum Cancer Centre, Australia, have now demonstrated that the gene responsible for making the Wnt signaling pathway inhibitor WIF1 is definitely silenced in individual osteosarcomas and that its absence in mice accelerated the development of radiation-induced osteosarcomas. The authors as a result conclude that targeting Wnt signaling pathway inhibitors is likely to boost susceptibility to osteosarcomas. Thus, both the authors and, within an accompany commentary, Greg Enders, at Fox Chase Cancers Center, Philadelphia, note that caution is needed before this approach is used in clinical trials to treat patients with bone loss disorders such as for example osteoporosis. Related StoriesNew antenna-like device makes breast cancer surgery much easier for surgeonsMeat-rich diet may increase kidney cancer riskMD Anderson study reveals why chemotherapy drugs not effective for many pancreatic cancer patients.. Continue reading